With reported surveillance compliance, test performance, and prevalence of cirrhosis and viral hepatitis in China,10, 44, 45, 46, 47, 48 Monte–Carlo simulation revealed that HepaAiQ could lead to a 2.5‐fold (95% CI: 1.8–3.4) increase in HCC detection compared to ultrasonography combined with AFP (Figure S10). This evidence concerns the gene AFP and viral hepatitis.