PheWAS results also revealed interesting pleiotropic effects of these genes, which have been shown to exert relevant functions in the identified phenotypes, such as the associations of NOD2 and hypercoagulability (286.81 and 286.8) [61] and asthma (495) [62], IL6ST and joint disease (727.4) [63] and systemic and cutaneous lupus erythematosus (695.4, 695.42, and 695.41) [64], and IFNAR1 and viral hepatitis [65]. The gene discussed is NOD2; the disease is asthma.