Administration of EVs co-delivering miR-21 inhibitor oligonucleotide and 5-FU to 5-FU-resistant CRC cells in tumor-bearing mice depicted diminished chemoresistance and enhanced apoptosis by restoring PTEN and human MutS homolog 2 (hMSH2) expression [251]. The gene discussed is PTEN; the disease is colorectal carcinoma.