A study unraveled that by shuttling miR-21-5p and miR-200a via EVs, CRC cells augment PD-L1 levels in M2 macrophages by suppressing PTEN and SOCS1 expression and upregulating AKT and STAT1 expression, resulting in M2 suppressive activity on CD8 + T cells [109]. This evidence concerns the gene CD274 and colorectal carcinoma.