Yang et al. revealed exosomal transfer of microRNA-106b-5p (miR-106b) originating from CRC cells which have undergone the EMT process, induce M2-like polarization by suppressing programmed cell death 4 (PDCD4) and activating PI3Kγ/Akt/mTOR axis. Here, MTOR is linked to colorectal carcinoma.