TGFB1 and malignant colon neoplasm: In another study, exosomal circPACRGL originated from colon cancer cells elevates the levels of TGF-β1 by sequestering miR-142-3p and miR-506-3p, thus expanding CRC growth, invasion and concomitantly inducing neutrophils differentiation toward tumor-promoting N2 neutrophils [92].