Women from the United States had a higher risk of skin cancer than those from Canada (HR = 1.98, 95% CI: 1.39, 2.83, p < 0.0001) for BRCA1 carriers and HR = 1.55 (95%CI 1.04–2.30; p = 0.03) for BRCA2 carriers (Tables3a and 3b). This evidence concerns the gene BRCA1 and skin cancer.