Of note, compared with those in T2DM patients, the peak area (after Log2 transformation) of Cer(d18:0/24:0) (20.48 ± 0.82 vs. 20.12 ± 0.99, p = 0.006, Fig. 2C) and Cer(d18:0/22:0) (19.91 ± 0.75 vs. 19.64 ± 0.92, p = 0.028, Fig. 2C) remained significantly lower in T2DM patients with DR, and the levels of these two lipids retained significant ORs when adjusted for known risk factors (i.e., CHOL, TG, LDL-c and HDL-c). Here, CBLN1 is linked to type 2 diabetes mellitus.