Sphingolipids, including ceramides (Cer), sphingomyelins (SM) and gangliosides, have a variety of intra- and extracellular effects on glucose homeostasis and metabolic disease [10] Numerous studies suggest Cer, a crucial lipid intermediate in sphingolipid metabolism, is a major contributing factor for insulin resistance, and inhibition or depletion of enzymes driving de novo ceramide synthesis can prevent the development of diabetes in mice [7, 11, 12]. This evidence concerns the gene INS and diabetes mellitus.