When comparing CRC incidences in carriers followed up in PLSD who were subjected to colonoscopy surveillance with other cohorts who did not receive colonoscopy surveillance, the CRC incidences in path_MLH1, path_MSH2 and path_MSH6 carriers were either increased or not reduced in PLSD, depending on which retrospective segregation analyses were used [10–13]. The gene discussed is MSH2; the disease is colorectal carcinoma.