TP53 and nasopharyngeal carcinoma: After testing the effect of Nutlin-3 on nasopharyngeal carcinoma and nasopharyngeal epithelial (NPE) cell lines, it was found that the drug more strongly inhibited the p53-MDM2 interaction in nasopharyngeal carcinoma cells (C666-1) than in NPE cells (NP69 and NP460) [79].