TP53 and neoplasm: To better understand why some samples exhibited large increases in MNR in tetraploid cells relative to diploid cells, we investigated in detail the TP53−/− 184-hTERT sample SA906a and the primary HGSC tumor SPECTRUM-OV-081, both of which demonstrated large, statistically significant differences in tetraploid versus diploid MNR (9.35% and 12.6%, respectively; one-sided Wilcoxon test, both P < 1.2 × 10−4).