Our results, showing that CHIP together with 5 other factors, four of which (old age, low levels of albumin, and DM) are characterized by chronic pro-inflammatory status72–74 suggest the notion of an increased risk of mortality in the studied population due to exacerbated inflammatory condition, based on the results of animal studies75 showing that CHIP acts by enhancing the inflammatory response. The gene discussed is STUB1; the disease is diabetes mellitus.