Regarding the association of HPR with the risk of primary endpoint, the present study found that the prognostic value of HPR was significantly improved with consideration of clinical risk factors and heart failure together irrespective of the presentation of AMI; however, further adjustment of high AIP could not improve the prognostic value of HPR in both non-AMI and AMI patients (Supplementary Table 2). The gene discussed is AIP; the disease is heart failure.