A recent report has compiled the E3 ubiquitin ligases explored in AD pathology [10] wherein the expression of NEDD4-1, MARCH8, RNF182 is upregulated in diseased conditions while the level of TTC3, Ube3A, CHIP, HRD1, and Parkin gets downregulated. The gene discussed is UBE3A; the disease is Alzheimer disease.