Individuals in the early stages of idiopathic membranous nephropathy exhibited elevated levels of circulating CD14 + /CD163 + , CD14 + /CD163 + /CD206 + , and CD14 + /CD163 + /CD206 + /CD115+ macrophages compared to healthy controls [148]. This evidence concerns the gene MRC1 and idiopathic membranous glomerulonephritis.