TLR4 and acute kidney injury: Hederasaponin C, a natural product, effectively inhibits lipopolysaccharide (LPS)-induced acute kidney injury in mice by specifically targeting Toll-like receptor 4 (TLR4) and modulating the phosphatidylinositol 4,5-bisphosphate (PIP2)/NF-κB/NLRP3 signaling pathway [254].