GPVI-expressing mice presented a positive z-scoring for genes related with melanoma progression and detrimental prognosis (Mlana, Mc1r, Rab38, Cd63, Mlph, Pmel, Myo7a, Satb2), immune checkpoint proteins (ICP) (Cd276, Sirpa, Lgals3) and cell cycle progression (Cdk1, Ccnb1, Cdca2, Ccda8, Cdc20, Cdc25a, Mcm2, Mcm3, Mcm5, Top2a, Birc5). The gene discussed is CDC20; the disease is melanoma.