GPVI-expressing mice presented a positive z-scoring for genes related with melanoma progression and detrimental prognosis (Mlana, Mc1r, Rab38, Cd63, Mlph, Pmel, Myo7a, Satb2), immune checkpoint proteins (ICP) (Cd276, Sirpa, Lgals3) and cell cycle progression (Cdk1, Ccnb1, Cdca2, Ccda8, Cdc20, Cdc25a, Mcm2, Mcm3, Mcm5, Top2a, Birc5). This evidence concerns the gene TOP2A and melanoma.