It confirmed that reducing the membrane repair activity by targeting the molecular in the dsDNA-AIM2-ZBP1-ASC-RIPK1-RIPK3-CASP1-CASP8-GSDMD-GSDME pathway could increase the sensitivity of tumor cell membranes to Triton X-100, but reduce the sensitivity to IFN-γ and TNF-α. The gene discussed is GSDMD; the disease is neoplasm.