We therefore used 3xTg-AD mice with typical pathological features, including the deposition of amyloid β-peptide, hyperphosphorylated tau, and increased oxidative stress, as animal model for the study of AD.47 The 3xTg-AD mice transplanted with hDPSCs exhibited improved spontaneous exploration and memory performance, as assessed by two well-defined and widely used cognitive (hippocampus-dependent) tasks. The gene discussed is MAPT; the disease is Alzheimer disease.