CD4 and neoplasm: A statistically significant association was also found between sarcomatoid features and number of CD4+ cells and ratio between CD4+ and CD8+ immune cells; numerically higher values of CD4+ cells (median 44 vs 16; p = 0.017) and higher CD4+/CD8+ ratio (median 2.10 vs 1.40; p = 0.016) were observed in tumor samples with sarcomatoid features.