ROS oxidized low-density lipoprotein (OxLDL), a risk factor for stroke, stimulates oxidative stress-induced secretion of HMGB1 in macrophages, and HMGB1 promotes macrophage-derived foam cell formation via the endoplasmic reticulum stress (ERS)/C/EBP-homologous protein (CHOP) pathway [80]. The gene discussed is DDIT3; the disease is Stroke.