HMGB1 and Cerebral ischemia: In a 2-h MCAO rat model, administration of anti-HMGB1 monoclonal antibody immediately and 6 h later after cerebral ischemia–reperfusion had a reducing effect on infarct volume in both the cerebral cortex and striatum of rats, with reductions of 90% and 75% at 24 and 48 h, respectively [133].