Notoginseng leaf triterpenes reduced HMGB1 expression, inhibited activation of MAPKs and NF-κB to suppress neuroinflammation, and suppressed microglia activation in the hippocampus and cortex, thereby facilitating cerebral ischemia–reperfusion-induced neuropathological changes [195]. The gene discussed is HMGB1; the disease is Cerebral ischemia.