MAPT and early-onset autosomal dominant Alzheimer disease: The defining feature of Alzheimer’s disease is the accumulation of toxic variants of amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta $$\end{document}β and tau protein aggregates throughout the brain (Duyckaerts et al.