MUC2 and obesity due to melanocortin 4 receptor deficiency: In vitro studies reported that 2’FL led to enhanced MUC2 expression and secretion on human GCs during inflammatory conditions.23 30 While, in vivo, 2′FL ameliorated colitis by recovering GC numbers and improving Muc2 expression in mice.22 23 However, no studies investigated the effect of 2’FL supplementation on the intestinal mucus in the context of HFD feeding and obesity.