Its C-terminal fibrinogen-like (FBN) domain is a ligand of macrophage integrin αvβ3.<h4>Objectives</h4>ANGPTL3 might home to plaque where it directly regulates macrophage function via integrin αvβ3 for atherosclerosis progression.<h4>Methods</h4>Ldlr<sup>-/-</sup> mice on a high-fat diet and ApoE<sup>-/-</sup> mice on a chow diet were received adeno-associated virus (AAV)-mediated Angptl3 gene transfer and followed up for 12 weeks. Here, ANGPTL3 is linked to atherosclerosis.