Patients with CI, even with schizophrenia and major depression, have higher circulating levels of inflammatory markers, including IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, soluble TNF receptor 1 (sTNFR1), sTNFR2, MCP-1, MCP-3, CRP, and high-sensitivity CRP (hsCRP) [13, 53-55]. This evidence concerns the gene IL10 and major depressive disorder.