Through gene editing, scientists generated iSPCs from fibroblasts and peripheral blood [119] of ALS patients with various mutations in TDP-43, including M337V [58, 120, 121] Q343R [58, 121], A382T [119, 122], N352S [65], I383V [123, 124] and G298S [58, 65, 123, 124]. Here, TARDBP is linked to amyotrophic lateral sclerosis.