Interestingly, insoluble inclusions are widely observed in these diseases and inferred as the main culprit in neurodegeneration pathology, such as microtubule-associated protein Tau (MAPT) cytosolic aggregates in AD (Alzheimer’s disease), alpha-synuclein (α-Syn) inclusion bodies or Lewy bodies in PD (Parkinson disease), TARDNA-binding protein 43 (TDP-43) or FUS intracytoplasmic inclusion bodies in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), and polyglutamine (PolyQ) aggregates in HD (Huntington disease). The gene discussed is SNCA; the disease is amyotrophic lateral sclerosis.