Interestingly, insoluble inclusions are widely observed in these diseases and inferred as the main culprit in neurodegeneration pathology, such as microtubule-associated protein Tau (MAPT) cytosolic aggregates in AD (Alzheimer’s disease), alpha-synuclein (α-Syn) inclusion bodies or Lewy bodies in PD (Parkinson disease), TARDNA-binding protein 43 (TDP-43) or FUS intracytoplasmic inclusion bodies in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), and polyglutamine (PolyQ) aggregates in HD (Huntington disease). This evidence concerns the gene MAPT and juvenile Huntington disease.