TARDBP and amyotrophic lateral sclerosis: To test this, we studied (i) the mechanism of protein-protein interaction between NF242 and TDP-43 in vitro and in silico; (ii) the co-expression of RGNEF or NF242 with TDP-43 in Drosophila melanogaster; and (iii) the viral ectopic expression of NF242 in an aggressive murine model of ALS (rNLS8).23