TARDBP and proteostasis deficiencies: This includes studies with small molecules, such as compounds containing extended planar aromatic moieties,66 ATP,67 the chemical rTRD0168 and an antibody against the RRM1 of TDP-43.69 These data support our findings demonstrating that targeting the RRM domains of TDP-43 can improve the phenotype of TDP-43 proteinopathies.