Considering that the rNLS8 mice have previously shown resistance to other therapeutic approaches, such as riluzole treatment,24 MMP-9 reduction73 or miR-23a suppression,74 the more encouraging evidence that we show in this work highlights the therapeutic potential of our approach after modifying the phenotype of this severe murine model of ALS. Here, MMP9 is linked to amyotrophic lateral sclerosis.