However, gene expression analysis yieldedmajor findings in PCa cells: (1) An increase in adhesion markers (PECAM1, CD34, CDH5) suggeststhat coculture with bone cells enhances the neovascularization potentialof PCa cells, which may serve as a molecular mechanism underlyingthe preferential spreading of PCa to bone in vivo. This evidence concerns the gene PECAM1 and posterior cortical atrophy.