Previous studies showedthat increased expression of CD34 confers tumor progressionand aggressiveness in prostate cancer,47 with a high expression of CD34 in tumor tissuethat suggests intensive tumor neovascularization.48 Expression of CDH5, encoding for VE-Cadherin,another glycoprotein important for cell–cell adhesion, signaltransduction, and for vascular remodeling49 is also higher in PCa cells when cocultured with bone cells (Figure 2C). This evidence concerns the gene CDH5 and prostate cancer.