HIPK2 and osteosarcoma: A recent bioinformatic study linkedfour key genes (KRT5, HIPK2, MAP3K5, and CD5) to osteosarcoma patientsurvival, with KRT5 expression positively correlatedwith survival risk.64 Other cell adhesionmarkers (PECAM1, CDH5, and MCAM) showed no clear changes upon coculture with PCa cells(Figure 4C).