CDH5 and Familial prostate cancer: Previous studies showedthat increased expression of CD34 confers tumor progressionand aggressiveness in prostate cancer,47 with a high expression of CD34 in tumor tissuethat suggests intensive tumor neovascularization.48 Expression of CDH5, encoding for VE-Cadherin,another glycoprotein important for cell–cell adhesion, signaltransduction, and for vascular remodeling49 is also higher in PCa cells when cocultured with bone cells (Figure 2C).