Transcriptomic data showed that “bona fide” NKB cells, i.e., cells with appreciable transcript levels of both B and NK cell hallmark genes, comprised only 20% of the total population of cells expressing the NKB surface phenotype (lin-CD20+NKGA/C+), thus undermining the functional relevance of this subset during infections and potential translation to therapeutic/vaccine development. Here, MS4A1 is linked to infection.