Partial deletion of 3p has been reported in almost all analyzed NSCLCs [29, 30], and contains numerous genes including FHIT (3p14.2), RASSF1 (3p21.3), TUSC2 (FUS1, 3p21.3), SEMA3B (3p21.3), SEMA3F (3p21.3) and MLH1 (3p22.3) where allelic imbalance of FHIT is associated with chromosomal deletions [31, 32], RASSF1 and MLH1 are inactivated by promoter hypermethylation [33–35], TUSC2 [36], SEMA3F and SEMA3B transcripts [37] are recurrently underrepresented in lung cancers and the SEMA3s were found to be targets of TP53 [38] could be potentially activated during DNA damage. This evidence concerns the gene SEMA3B and lung cancer.