The analysis clarified that CASC2 is better than MALAT1 in the prediction of the HCC among HCV patients, but we need to stress on CASC2 cut-off value that performs best accuracy and sensitivity is (0.995), which is near to the control (1.03±0.02) which are a healthy individual with no pre-hepatic condition but in case of our patient who had HCV infection (14.9±3.6) with the major part of them showed significant up-regulation will be markedly discriminating. The gene discussed is MALAT1; the disease is hepatocellular carcinoma.