RIPK1 and B-cell chronic lymphocytic leukemia: Interestingly, the number of apoptotic hepatocytes in RIPK1-edited and CLL-treated mice was lower than in RIPK1-edited non CLL-treated mice (Fig 3E), and liver histology revealed the presence of necrotic areas (Fig 3F), indicating most likely the activation of a death mechanism other than apoptosis.