LARP1B, PDIA5 and CDK5 are closely related to the occurrence of tumors and cancers, indicating that NENF and LARP1B, PDIA5 and CDK5 have antagonistic or synergistic effects in the development of obesity,19–21CASC4 causes breast cancer to occur,22ALDOC plays an important role in the decomposition of carbohydrates during fat hydrolysis, which suggests that ALDOC and NENF may have antagonistic effects in adipogenesis,23 and CYB5A is closely associated with meat flavor.24 Here, CYB5A is linked to obesity due to melanocortin 4 receptor deficiency.