Central precocious puberty (CPP) refers to hypothalamic-pituitary–gonadal axis (HPGA) initiation in advance because of the various factors, resulting in a higher level of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and follicle stimulating hormone (FSH), influencing on the ovary or testis, finally resulting in increased level of sex hormone, advanced clinical secondary characteristics and bone age [1].The incidence of precocious puberty in China was 11.47% in girls and 3.26% in boys [2]. Here, PLOD1 is linked to precocious puberty.