SIRT1 and gout: <h4>Objective and design</h4>To elucidate Sirt1's role in gouty arthritis inflammation and its potential mechanisms.<h4>Material</h4>Constructed murine models of gouty arthritis and conducted THP-1 cell experiments.<h4>Treatment</h4>1 mg of MSU crystals injected into mice ankle joints for a 72-h intervention.