Intriguingly, there was also no difference in the growth rate of mouse HCC cell line Hepa1-6 cells expressing LDHB compared with control cells in immunodeficient BALB/c nude mice, but the growth rate of Hepa1-6 cells expressing LDHB was significantly inhibited in immunocompetent C57BL/6 mice. This evidence concerns the gene LDHB and hepatocellular carcinoma.