LDHB and liver cancer: Some studies suggested that LDHB was essential for the proliferation of non-small cell lung cancer (NSCLC) and triple-negative breast cancer cells [35–37], whereas others reported that LDHB downregulation or loss was an important event in cancer development [13], including prostate, breast, pancreatic and liver cancers [17, 18, 27, 38], and was associated with rapid proliferation, accelerated tumor cell invasion and shorter patient survival outcomes [19, 20, 39, 40], indicating that LDHB may serve as a tumor suppressor in these cancers.