KLHL17, NLRC5, SEC24C, and ZBTB17 are upregulated in the disease group (AS or AD), while BEX2, C11orf73 (HIKESHI), NKRF, SOD1, UBL5, UFC1, and ZNHIT3 (zinc finger HIT‐type containing 3) are downregulated in the disease group (Table S5, Figure S2). This evidence concerns the gene HIKESHI and Alzheimer disease.