The results of the analysis demonstrated significant inhibition in the progression of Alzheimer's disease (AD) in NKRF knock‐in (NKRF) and ZBTB17 knockout (ZBTB17−/−) mice compared to the model mice (3×Tg and 3×Tg/ApoE−/− + HFD). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.