The above in vivo validation experiments show that BEX2, NKRF, SOD1, UBL5, ZBTB17, and ZNHIT3 exhibit differential expression in brain tissue, aorta tissue, and PBMC of AD, AS, and AD and AS mice, and their expression patterns are consistent with the results of a meta‐analysis. This evidence concerns the gene ZBTB17 and Alzheimer disease.