Among these, 11 genes (HEATR1, SEC24C, HGS, OR2L2, ZBTB17, NLRC5, VPS16, POLR3A, TTC17, KLHL17, and CHD8) were upregulated, and 10 genes (BEX2, ZNHIT3, UFC1, MGST3, SOD1, UBL5, MK167IP (NIFK), TXN, NKRF, and C11orf73 (HIKESHI)) were downregulated in AD or AS (Figure 1D). Here, OR2L2 is linked to Alzheimer disease.