CHD8 and Alzheimer disease: Among these, 11 genes (HEATR1, SEC24C, HGS, OR2L2, ZBTB17, NLRC5, VPS16, POLR3A, TTC17, KLHL17, and CHD8) were upregulated, and 10 genes (BEX2, ZNHIT3, UFC1, MGST3, SOD1, UBL5, MK167IP (NIFK), TXN, NKRF, and C11orf73 (HIKESHI)) were downregulated in AD or AS (Figure 1D).