Moreover, aromatase gene mutation and elevated levels of endocrine disruptors that bind to and interfere with estrogen receptor action during pregnancy lead to T2DM in offspring (Fukami et al. 2009, Czajka-Oraniec & Simpson 2010, Schönfelder et al. 2002, Alonso-Magdalena et al. 2010, Chevalier & Fénichel 2015). Here, ESR1 is linked to type 2 diabetes mellitus.