Increased eIF4F activity promotes the translation of mRNAs involved in cell proliferation and survival, and tumor immune evasion, which are hallmarks of cancer (Boussemart et al., 2014; Cerezo et al., 2018; Malka-Mahieu et al., 2017; Pelletier et al., 2015). The gene discussed is EIF4G1; the disease is cancer.