Furthermore, the mechanism of tumour termination also led to further CAR T-cell generation, such as IL-12 secretion and the incorporation of the inducible caspase 9 (iCasp9) suicide gene in the 4th generation CAR T-cell therapy to overcome tumour immunosuppression, and the 5th generation CAR T-cell therapy which is currently under development [4]. This evidence concerns the gene CASP9 and neoplasm.