m6A methylation represents the most prevalent form of mRNA modification, known to influence mRNA stability, localization, and alternative splicing by modulating modifications in the protein-coding sequences (CDS) and untranslated regions (UTR).6 Accumulating evidence suggests that m6A modification plays pivotal roles in the pathogenesis of various cancers and contributes to drug resistance, including in CC.7,8 Methyltransferase-like 14 (METTL14), a key component of the methyltransferase complex, has been found to be essential for m6A modification. The gene discussed is METTL14; the disease is cancer.