Previous studies have demonstrated that the PI3K/Akt signaling pathway is commonly aberrantly activated in various tumors, such as hepatocellular carcinoma21 and colorectal cancer.22 Evidence indicated that inhibiting the PI3K/Akt pathway may sensitize cancer cells to ferroptosis induction, offering a promising strategy to prevent carcinogenic progression.23 Therefore, for further exploration of the underlying signaling pathway, we investigated the effects of METTL14 and FTH1 on the PI3K/Akt pathway. Here, FTH1 is linked to colorectal cancer.