The lactate produced by tumor glycolysis, serving as a proinflammatory and immunosuppressive mediator within the tumor microenvironment, is modulated by METTL14-mediated m6A methylation, influencing the polarization of macrophages.27 Our study identifies that METTL14 and m6A modification are significantly downregulated in CC and that there is a correlation between METTL14 levels and poor prognosis in CC. This evidence concerns the gene METTL14 and neoplasm.