YTHDF2 and hepatocellular carcinoma: Another study highlighted that hypoxia suppresses METTL14 in a HIF-1α-dependent manner and that METTL14 mediates m6A modification of SLC7A11 mRNA at its 5′-UTR, leading to a decrease in SLC7A11 expression via a YTHDF2-dependent pathway, thus inhibiting ferroptosis in hepatocellular carcinoma.17 In our investigations, we also explored ferroptosis and discovered that METTL14 is upregulated in sorafenib-induced ferroptosis while silencing METTL14 significantly inhibits sorafenib-induced ferroptosis in CC.