TP53 and neoplasm: While the exact mechanism of p53 reactivation by APR-246/MQ is not fully understood, it has been reported that MQ reacts with cysteine residues C124, C229, and C277 in the core of mutant p53 proteins, thereby changing their conformation from mutant to WT and resulting in the restoration of transactivation of WT p53 target genes that inhibit tumor growth[49–50].