AKT1 and metastatic malignant neoplasm: The phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway participates in migration process of metastatic cancer cells, including the regulation of cytoskeleton-remodeling proteins and EMT–activating proteins that specifically regulate cell motility (Xue et al., 2012; Xue and Hemmings, 2013).