In this study, we found that FYD inhibits cancer cells migration and invasion by inhibiting the EMT, PI3K/AKT, and FAK signal cascades (Figure 4; Figure 5), due to the fact that FYD contains multiple active components (including Scutellarin (Li et al., 2019; Wang et al., 2019), Ganoderic Acid A (Cheng and Xie, 2019), Fraxetin (Ma et al., 2022), Butein (Rampogu et al., 2021), et al.)that can act on these signaling pathways simultaneously. Here, PTK2 is linked to cancer.