GPX4 and gastric cancer: For example, Ni et al. used atranorin complexes comprising superparamagnetic iron oxide nanoparticles (SPIONs) (Atranorin@SPION) to induce ferroptosis in GCSCs by decreasing the expression level of the Xc−/GPX4 axis and enhancing the 5-hydroxymethylcytosine modification of mRNAs in the pathway, thereby achieving therapeutic effects on gastric cancer (Ni et al., 2022b).