FDA: Food and Drug Administration; ER: extended-release; IR: immediate-release; GLP-1: glucagon-like peptide 1; GIP: glucose-dependent insulinotropic peptide; T2DM: type 2 diabetes mellitus; SQ: subcutaneous; PO: oral; ASA: American Society of Anesthesiologists. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.