CCL2 and Hepatic fibrosis: Glucocorticoid treatment can regulate the expression of MCP-1 in the liver of cholestatic rats and reduce the infiltration of inflammatory cells.24 25 Ramm et al26 found that bile acid-induced upregulation of hepatocyte-derived MCP-1 expression led to the recruitment of hepatic stellate cells and was a critical early event in the development of liver fibrosis.