Our study identified three inflammatory cytokines (eotaxin, G-CSF, MCP-1/MCAF), three immune cell traits (CD8dim NKT counts, CD8dim NKT/T cells ratio, CD8dim NKT/lymphocyte ratio), and one metabolite (X-12261 levels) as having a significant causal relationship with BA. Here, CSF3 is linked to breast angiosarcoma.