It has been described that isoflavonoids can regulate the EMT process and, as a consequence, decrease the invasive potential of tumor cells by promoting the expression of epithelial phenotype markers such as E-cadherin and reducing the expression of mesenchymal markers such as N-cadherin, Snail, Slug, and Twist (Hsiao, Ho & Pan, 2020; Liskova et al., 2020). Here, TWIST1 is linked to neoplasm.