Varied levels of KCC2 expression and related chloride transport irregularities can directly impact the inhibitory actions of GABA, contributing to diverse neurological diseases such as epilepsy (McMoneagle et al., 2023), schizophrenia (Cherubini, Di Cristo & Avoli, 2021), and chronic pain (Aby et al., 2022). The gene discussed is SLC12A5; the disease is epilepsy.