Inspired by the connection between “BTZ, ROS, NF‐κB signal, and CSCs” and the crucial role of IL‐33 in ROS generation, we hypothesized that IL‐33 could enhance the sensitivity of MM cells to BTZ through ROS‐mediated inhibition of NF‐κB signal and stemness properties. Here, NFKB1 is linked to Miyoshi myopathy.