When premature CAD was further classified into subcategories, the association remained significant between elevated Lp(a) level and increased risk of angiographically proven CAD (OR: 3.36, 95% CI: 2.09–5.40, P < 0.001), stable angina and ACS (OR: 2.95, 95% CI: 2.15–4.04, P < 0.001), ACS only (OR: 2.70, 95% CI: 1.92–3.81, P < 0.001), as well as MI (OR: 1.88, 95% CI: 1.53–2.32, P < 0.001) (Figure 3D). The gene discussed is LPA; the disease is angina pectoris.