A total of three studies reporting the association between Lp(a) and composite ASCVD, which suggested that compared with lower Lp(a), elevated Lp(a) level was associated with significant higher risks of composite ASCVD events among individuals at an early age (OR: 2.15, 95% CI: 1.53–3.02, P < 0.001) (Figure 2A). This evidence concerns the gene LPA and atherosclerosis.