As for the individual ASCVD events, there was a positive association between Lp(a) levels with risk of premature CAD (OR: 2.44, 95% CI: 2.06–2.90, P < 0.001) and PAD (OR: 2.56, 95% CI: 1.56–4.21, P < 0.001) but not for stroke (OR: 1.25, 95% CI: 0.87–1.81, P = 0.06) (Figure 3C). Here, LPA is linked to peripheral arterial disease.