Lp(a) is an LDL-c-like particle derived in the liver, which is covalently bound to apolipoprotein (apo) B100 by apo(a).31 It is the major carrier of oxidized phospholipid and promotes atherosclerotic plaque development through the pro-inflammatory, pro-thrombotic, and anti-fibrinolytic effects.26,31–36 In our meta-analysis, we found that genetically determined high Lp(a) is an independent predictor of premature ASCVD. The gene discussed is APOB; the disease is atherosclerosis.