LPA and atherosclerosis: The BIOSIGNAL study has observed a significant association between elevated Lp(a) and large artery atherosclerosis (LAA) stroke amongst individuals aged <60 years.6 A prospective study of 3596 patients by Raitakari et al.7 also found that higher Lp(a) was related to premature ASCVD, whereas Cai et al.8 and Shi et al.9 reported no significant relationship between Lp(a) and acute myocardial infarction (AMI) at the early age.