A total of two studies focused on patients with type 2 diabetes mellitus; the pooled results of these two studies suggested a significant association between elevated Lp(a) with premature ASCVD events among T2DM population (OR: 2.23; 95% CI: 1.54–3.23, P < 0.001) (Figure 3B), in relation to those with lower Lp(a). Here, LPA is linked to atherosclerosis.