ALOX5 and neoplasm: While the function of GSDMB in anti-tumor immunity through pyroptosis is well characterized [11,60], GSDMB was also reported to have pyroptosis-independent function such as its regulation of PDGF-A-mediated FAK phosphorylation [14], MAVS-TBK1 signaling [90] and 5-lipoxygenase (5-LO)-mediated TGF-β1 expression [13].