Also, with recent evidence suggesting a potential association between KCNQ2 mutations and altered pain perception [20, 21], we cannot exclude that the identified VoUS in KCNQ2 may contribute to the distally distributed burning symptoms complained by our patient, even though the identified variant has never been described in patients with neuropathic pain or small fiber neuropathy. The gene discussed is KCNQ2; the disease is neuropathy, small fiber.