To investigate the role of selected hub genes (ITGB1, COL1A1, COL1A2, COL4A1, FN1, COL6A3, THBS2, THBS1, and PCK1) in the development of IM to adenocarcinoma, possible microRNAs that might interact with these genes via the MirWalk database were predicted, and the miRTarBase filter was considered. This evidence concerns the gene COL4A1 and adenocarcinoma.